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KMID : 0616120210520020084
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Korean Journal of Pharmacognosy
2021 Volume.52 No. 2 p.84 ~ p.91
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The Melanin Synthesis Inhibitory Effect of Aspergillus fumigatus Fermented Extract
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Song Tae-Yang
Kim Chang-Won
Kang Mi-Ok
Gal Sang-Wan
Hwang Eul-Moon
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Abstract
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This study was carried out to investigate the melanin synthesis inhibitory effect of Aspergillus fumigatus fermented extract. In this study, we revealed the effects of A. fumigatus fermented extract on melanin contents, mushroom tyrosinase activity, and expression levels of mRNA and proteins of melanogenesis-related gene in B16F10 melanoma cells. A. fumigatus fermented extract inhibited both melanin contents and tyrosinase activity. In addition, the expression level of mRNA or proteins of melanogenesis was down-regulated in the A. fumigatus fermented extract treated B16F10 cells with dose-dependent manner. Moreover, when the clinical test was conducted, it was confirmed that the use of the fermented extract of A. fumigatus for 8 weeks improved skin brightness 1.586 times brighter and skin melanin 1.331 times better compared to the control product. Taken together, our results suggest that A. fumigatus fermented extract has melanogenesis inhibitory effect and whitening activity, thus it showed the possibility for using as a functional whitening cosmetic resource.
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KEYWORD
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Aspergillus fumigatus, Melanin, Tyrosinase, Cosmetic resource
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